Esophageal Cancer - Esophageal cancer is the third most common gastrointestinal cancer and the sixth most frequent cause of cancer death in the world, Dr. Chen said. About 16,000 new cases of esophageal cancer a year are diagnosed in the U.S., according to the American Cancer Society.
Dr. Chen and a group of researchers are studying esophageal squamous cell carcinoma, the dominant type of esophageal cancer world-wide. They are looking at whether food or other substances might prevent cancer. Previous work showed that freeze-dried strawberries were able to significantly inhibit tumor development in rats.
The research team designed a small study in humans and approached the California Strawberry Commission, which agreed to fund the study and make available the freeze-dried strawberries. The commission is a state agency funded by the strawberry industry.
Dr. Chen's team recruited 38 people in China who had mild-to-moderate dysplasia in the esophagus; 36 people completed the study. Biopsies of the esophagus were taken before and after the study. On average, patients were about 55 years old.
They were instructed to consume 30 grams of freeze-dried strawberries dissolved in a glass of water twice daily for a total of 60 grams a day for six months. Dr. Chen said the freeze-dried substance is about 10 times as concentrated as fresh strawberries, but suggested people could still benefit from eating whole strawberries on a daily basis.
Overall, the results showed 29 out of 36 participants experienced a decrease in histological grade of the precancerous lesion, or a slowing in the growth of the lesion during the study. Dr. Chen said larger, randomized placebo-controlled studies are needed to confirm the results. She said it isn't clear exactly what the anti-cancer agent in strawberries might be. But she noted that strawberries contain a variety of vitamins, minerals and other substances known as phytochemicals, which are also found in some other types of berries.
